Apoptosis in cancer

Apoptosis is a programmed cell death mechanism, with its presence and absence, directs the progression of most diseases targeted in disease treatments. Many factors are influential cell's pathway to apoptosis. The defects these pathways may transform become malignant, organism face lethal outcome such as cancer. Understanding apoptosis will provide clues guiding pathogenesis diseases. Two main leading apoptosis, intrinsic extrinsic, take an active role. Another route activated by enzymes secreted immune cells T NK. With their initiator enforcer roles, many caspase molecules at critical points process. In cancer treatments, activation repair disrupted among target approaches. This review discuss strategies for inhibiting apoptotic pathways.